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We develop the time-resolved techniques of X-ray crystallography and vibrational spectroscopy, and study protein reaction dynamics at the atomic and electronic levels in real time.
We reconstitute the macromolecular complexes with chromatin and determine their three dimensional structures by cryo-EM.
We develop the new method in cryoEM single particle analysis to visualize conformational ensembles of membrane proteins in function.
We develop the methods for preparation of biomolecules reflecting their dynamic functional states and operate an integrated structural analysis pipeline including cryo-electron microscopy.
We carry out single particle cryo-EM and crystallography of membrane protein complexes, and develop methodologies for higher-resolution cryo-EM and analyses of charge information and multi conformational states.
Microtubule is a dynamic cytoskeleton and playing various essential roles in living cells. To investigate their regulation, we examine the dynamic conformational changes of tubulin subunits in microtubules by using various measurement technologies.
The purpose of this research is development of an efficient synthetic route to various pi-conjugated systems based on the reaction integration using the reactive molecules, having potentially attractive reactivities. Three kinds of activations by heat, light, and transition metal catalyst enable the selective construction of complex structures by introducing diverse functionalities.
We analyze functionally important but hidden dynamics of drug-target proteins by using NMR spectroscopy. We also tackle the triplet DNP application to membrane-related proteins.
We have taken a challenge to develop a facile method to conjugate key molecule “Pentacene” with various biomolecules
We will develop the new method for observing molecular interaction using sensitivity-enhanced NMR spectroscopy by Triplet-DNP.
We will develop a method to hyper-polarize biomolecules using laser and microwave for sensitivity-enhanced NMR spectroscopy.
We develop new algorithms to construct 3D models and obtain dynamical information from Cryo-EM experimental data of biological molecules
We develop fragment-based modeling of structures for cryo-EM map fitting and the refinement of cryo-EM structures using fragment-assembly.
We try to characterize and address sequence-dependent nucleosome stability using all atom simulations, bioinformatics and FRET experiments. In particular, we focus on +1 nucleosomes and elucidate the functional role in gene regulation.
We develop coarse-grained models for protein-DNA complexes and apply them to pursue dynamic aspects of nucleosome structures and their correlation with transcription activity.
We develop the new parallelization algorithm and multi-scale algorithm for the fast and reliable cryo-EM flexible fitting simulations of large biomolecular systems.
We perform multiscale molecular dynamics simulations in combination with structural biology experiments such as small-angle x-ray scattering (SAXS) and NMR.
We develop the new special-purpose computer MDGRAPE-4A for all atom simulations of biomolecules and perform unbiased microseconds simulations of target proteins.
We develop the time-resolved techniques of X-ray crystallography and vibrational spectroscopy, and study protein reaction dynamics at the atomic and electronic levels in real time.
We reconstitute the macromolecular complexes with chromatin and determine their three dimensional structures by cryo-EM.
We develop the new method in cryoEM single particle analysis to visualize conformational ensembles of membrane proteins in function.
We develop the methods for preparation of biomolecules reflecting their dynamic functional states and operate an integrated structural analysis pipeline including cryo-electron microscopy.
We carry out single particle cryo-EM and crystallography of membrane protein complexes, and develop methodologies for higher-resolution cryo-EM and analyses of charge information and multi conformational states.
Microtubule is a dynamic cytoskeleton and playing various essential roles in living cells. To investigate their regulation, we examine the dynamic conformational changes of tubulin subunits in microtubules by using various measurement technologies.
The purpose of this research is development of an efficient synthetic route to various pi-conjugated systems based on the reaction integration using the reactive molecules, having potentially attractive reactivities. Three kinds of activations by heat, light, and transition metal catalyst enable the selective construction of complex structures by introducing diverse functionalities.
We analyze functionally important but hidden dynamics of drug-target proteins by using NMR spectroscopy. We also tackle the triplet DNP application to membrane-related proteins.
We have taken a challenge to develop a facile method to conjugate key molecule “Pentacene” with various biomolecules
We will develop the new method for observing molecular interaction using sensitivity-enhanced NMR spectroscopy by Triplet-DNP.
We will develop a method to hyper-polarize biomolecules using laser and microwave for sensitivity-enhanced NMR spectroscopy.
We develop new algorithms to construct 3D models and obtain dynamical information from Cryo-EM experimental data of biological molecules
We develop fragment-based modeling of structures for cryo-EM map fitting and the refinement of cryo-EM structures using fragment-assembly.
We try to characterize and address sequence-dependent nucleosome stability using all atom simulations, bioinformatics and FRET experiments. In particular, we focus on +1 nucleosomes and elucidate the functional role in gene regulation.
We develop coarse-grained models for protein-DNA complexes and apply them to pursue dynamic aspects of nucleosome structures and their correlation with transcription activity.
We develop the new parallelization algorithm and multi-scale algorithm for the fast and reliable cryo-EM flexible fitting simulations of large biomolecular systems.
We perform multiscale molecular dynamics simulations in combination with structural biology experiments such as small-angle x-ray scattering (SAXS) and NMR.
We develop the new special-purpose computer MDGRAPE-4A for all atom simulations of biomolecules and perform unbiased microseconds simulations of target proteins.